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Updated: Aug 2, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
Published on: January 25, 2016
Acetylcholine liberation from cerebral cortex during paradoxical (REM) sleep
Abstract:
The rate of liberation of free acetylcholine from the surface of prostigmin-treated cerebral cortex in the freely moving cat has been determined in states of slow wave sleep, paradoxical or activated sleep, and waking. The average rate during slow wave sleep (1.2 nanograms per minute per square centimeter of cortical surface) increased during paradoxical sleep (2.2 nanograms per minute) and during waking (2.1 nanograms per minute). The rate of acetylcholine release is thus related to the electroencephalogram pattern of desynchronized activatin of the cortex rahter than to the behavioral responsiveness of the animals.
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