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[Cimetidine versus antacids].

Schweizerische Medizinische Wochenschrift

|April 7, 1979

Summary

This summary is machine-generated.

Cimetidine and antacids reduce stomach acid for ulcer treatment. Cimetidine demonstrates superior healing and recurrence prevention for duodenal ulcers compared to high-dose antacids, considering patient factors.

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Area of Science:

Gastroenterology
Pharmacology

Background:

Gastric acid suppression is key in ulcer therapy.
Cimetidine and antacids are common treatments.

Purpose of the Study:

Compare the efficacy of cimetidine and antacids in treating duodenal ulcers.
Evaluate long-term recurrence prevention and patient acceptability.

Main Methods:

Cimetidine inhibits gastric acid secretion by over 50% in 24 hours.
High-dose antacids (250 ml/day) achieve similar acute effects.
Cimetidine shows superior inhibition of nocturnal acid secretion.

Main Results:

Cimetidine heals duodenal ulcers in ~80% of patients within 4-6 weeks.
A low evening dose of cimetidine prevents recurrence in ~50% within a year.

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Antacids show similar acute healing rates but their long-term recurrence prevention is unknown.

Conclusions:

Cimetidine is superior to high-dose antacids regarding healing, recurrence prevention, acceptability, side effects, and cost.
Low-dose antacids remain a viable option for uncomplicated ulcers in Europe due to high spontaneous healing rates.