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Evaluation of a new method for treating segmental renal disease
Surgery, Gynecology & Obstetrics
|May 1, 1979
Summary
Therapeutic segmental renal artery embolization is a feasible treatment for segmental renal disease. This study demonstrated its safety and effectiveness in canine models, with most dogs remaining normotensive post-procedure.
Area of Science:
- Interventional Radiology
- Nephrology
- Vascular Surgery
Background:
- Segmental renal artery embolization is an emerging technique.
- Assessing the feasibility of therapeutic segmental renal embolization is crucial for clinical application.
Purpose of the Study:
- To evaluate the feasibility and safety of therapeutic segmental renal artery embolization.
- To assess the impact of segmental renal embolization on blood pressure and plasma renin activity.
Main Methods:
- Experimental study using a two-kidney and one-kidney dog model.
- Segmental renal artery embolization performed using Gelfoam, Silastic elastomer, and barium sulfate.
- Monitoring of blood pressure, plasma renin activity, and renal arteriograms.
Main Results:
- 17 out of 18 dogs remained normotensive after segmental renal embolization.
- One dog developed persistent hypertension, managed with total renal embolization.
- Three dogs in the control group died due to unintentional complete renal embolization.
Conclusions:
- Therapeutic segmental renal embolization is a feasible method for treating segmental renal disease.
- The procedure appears safe and effective in maintaining normotension in most cases.
- Further research is warranted to optimize techniques and patient selection.