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Peripheral neuropathy after disulfiram administration.

C Gardner-Thorpe, S Benjamin

    Journal of Neurology, Neurosurgery, and Psychiatry
    |June 1, 1971
    PubMed
    Summary
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    Disulfiram can cause toxic effects like peripheral neuropathy and optic neuritis in alcoholics. Recognizing this drug toxicity is crucial for patient management to avoid continued administration.

    Area of Science:

    • Neurology
    • Toxicology
    • Pharmacology

    Background:

    • Alcohol use disorder is a significant public health issue.
    • Disulfiram is a commonly prescribed medication for alcohol dependence.
    • Neurological complications can arise in patients undergoing treatment for alcoholism.

    Purpose of the Study:

    • To investigate the neurotoxic effects of disulfiram.
    • To differentiate disulfiram-induced neuropathy and optic neuritis from alcohol-related conditions.
    • To highlight the importance of considering disulfiram toxicity in patient management.

    Main Methods:

    • Review of previous case reports on disulfiram-induced neurological issues.
    • Description of six new cases presenting with peripheral neuropathy or optic neuritis.

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  • Discussion of the mechanisms of disulfiram's effects on the nervous system.

    • Main Results:

    • Disulfiram toxicity can manifest as peripheral neuropathy and optic neuritis.
    • Previous literature documented 16 cases of neuropathy and six of optic neuritis potentially linked to disulfiram.
    • Six additional cases of disulfiram-induced neurotoxicity are presented.

    Conclusions:

    • Disulfiram can cause significant neurological damage, including peripheral neuropathy and optic neuritis.
    • Failure to identify disulfiram as the causative agent can lead to its continued administration.
    • Clinical awareness and consideration of disulfiram toxicity are essential for appropriate patient care in alcohol-dependent individuals.