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Related Experiment Videos

Coagulation factor activity in platelet concentrates.

T L Simon, R Henderson

    Transfusion
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Platelet concentrates maintain most coagulation factors for 72 hours. Factor V and VIII levels decrease, especially at 22°C, but platelet products remain valuable for coagulation factor activity.

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    Area of Science:

    • Transfusion Medicine
    • Hematology
    • Biochemistry

    Background:

    • Platelet concentrates are critical in managing bleeding disorders.
    • Understanding coagulation factor stability in stored platelets is essential for transfusion efficacy.
    • Previous research has not fully elucidated the impact of storage conditions on specific coagulation factors within platelet products.

    Purpose of the Study:

    • To investigate the activity of key coagulation factors (II, V, VII, VIII, IX, X, XI, XII) and fibrinogen in platelet concentrates.
    • To assess the influence of storage temperature (4°C vs. 22°C) and agitation on coagulation factor levels.
    • To compare the stability of coagulation factors in platelet concentrates versus platelet-poor plasma.

    Main Methods:

    • Platelet concentrates were stored at 4°C and 22°C, with and without agitation.

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  • Coagulation factor activities and fibrinogen levels were measured at baseline and up to 72 hours.
  • Factor V and VIII stability was compared between platelet concentrates and platelet-poor plasma from the same blood units.

    • Main Results:

    • Coagulation factors II, VII, IX, X, XI, XII, and fibrinogen remained stable for 72 hours at both 4°C and 22°C.
    • Factor V activity significantly decreased, particularly at 22°C (47% activity at 72 hours) compared to 4°C (78% activity at 72 hours).
    • Factor VIII activity decreased to approximately 68% at 72 hours at both temperatures; its decline was less pronounced in the presence of platelets.

    Conclusions:

    • Platelet concentrates effectively preserve most coagulation factors for up to 72 hours.
    • Storage temperature significantly impacts Factor V stability, with higher losses at 22°C.
    • Platelet concentrates are a valuable source of coagulation factor activity and should be considered in component therapy programs.