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Strontium induced rickets: metabolic basis.

J L Omdahl, H F DeLuca

    Science (New York, N.Y.)
    |November 26, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Dietary strontium hinders vitamin D activation and calcium absorption in chicks. Supplementation with 1,25-dihydroxycholecalciferol reversed these effects, suggesting strontium induces rickets by blocking this key vitamin D metabolite.

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    A new, highly sensitive assay for 1,25-dihydroxyvitamin D not requiring high-performance liquid chromatography: application of monoclonal antibody against vitamin D receptor to radioreceptor assay.

    Analytical biochemistry·1992

    Area of Science:

    • Nutritional biochemistry
    • Endocrinology
    • Mineral metabolism

    Background:

    • Vitamin D is crucial for calcium absorption and bone health.
    • 1,25-dihydroxycholecalciferol is the active form of vitamin D in the intestine.
    • Dietary factors can interfere with vitamin D metabolism and calcium homeostasis.

    Purpose of the Study:

    • To investigate the effect of dietary strontium on vitamin D metabolism and intestinal calcium absorption in chicks.
    • To determine the role of 1,25-dihydroxycholecalciferol in mediating the effects of strontium.

    Main Methods:

    • Chicks were fed a diet supplemented with strontium.
    • Calcium absorption and vitamin D metabolite levels were measured.
    • The effects of 1,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol were assessed.

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    Main Results:

    • Dietary strontium significantly inhibited the synthesis of 1,25-dihydroxycholecalciferol.
    • Strontium also reduced intestinal calcium absorption in vitamin D(3)-repleted chicks.
    • Administration of 1,25-dihydroxycholecalciferol normalized calcium absorption, while 25-hydroxycholecalciferol had no effect.

    Conclusions:

    • Strontium interferes with the intestinal biosynthesis of 1,25-dihydroxycholecalciferol.
    • This inhibition of 1,25-dihydroxycholecalciferol synthesis is the likely mechanism by which strontium induces rickets.
    • Vitamin D metabolism is sensitive to dietary mineral composition.