[Effect of qualitatively varied nutrition on the lipoprotein lipase activity in rat tissues]

Isocaloric food rations with a steady protein level, but differing proportions and quality of carbohydrates and fat produce a marked effect on the activity of the lipoprotein lipase in the fat tissue and liver of rats, affecting the blood insulin level to a lesser degree. In investigated tissues a reduced activity of the enzyme was noted to occur by using a ration carrying an excess amount of animal fat and of a diet with saccharose balanced in proportions of carbohydrates and fat. A fat-rich ration with a vegetable oil and a carbohydrate-rich ration with saccharose heighten the activity of the lipoprotein lipase both in the fat tissue and in the liver, but produce an opposite action on the blood insulin concentration. The absence of direct relation between the activity of the enzyme and the blood insulin level indicates that under the effect of food differed by its chemical composition the blood insulin concentration is not a decisive factor in regulating the activity of the lipoprotein lipase in tissues.