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[Theophylline therapy--foundations and possibilities (author's transl)]
Zeitschrift Fur Erkrankungen Der Atmungsorgane
|January 1, 1979
Summary
Theophylline is a key drug for bronchial asthma therapy, but its therapeutic and toxic levels are very close. Regular plasma concentration monitoring is crucial for safe and effective treatment, especially with complicating health conditions.
Area of Science:
- Pharmacology
- Clinical Medicine
- Respiratory Medicine
Context:
- Theophylline is a vital medication for managing bronchial asthma.
- A narrow therapeutic index necessitates careful dosing and monitoring.
- Pharmacokinetic variability is influenced by numerous patient-specific factors.
Purpose:
- To highlight the critical need for therapeutic drug monitoring of theophylline.
- To emphasize the close proximity of therapeutic and toxic concentrations.
- To underscore the impact of endogenous and exogenous factors on theophylline pharmacokinetics.
Summary:
- Theophylline, a primary treatment for bronchial asthma, exhibits a narrow therapeutic window, making precise concentration control essential.
- Pharmacokinetics of theophylline are significantly influenced by various internal and external factors, leading to potential rapid changes.
- Regular estimation of plasma or serum theophylline levels is imperative for optimizing treatment efficacy and safety.
Impact:
- Informed clinical decisions regarding theophylline dosage adjustments.
- Improved patient outcomes through minimized risk of toxicity and enhanced therapeutic benefit.
- Foundation for personalized asthma management strategies based on individual pharmacokinetic profiles.