[Anatomical distribution of a CCK-oktapeptide like substance in the human brain (author's transl)]

Using Gastrin 14-17 as immunogen it was possible to raise an antiserum, which showed a high sensitivity for the C-terminal octapeptide of CCK in a radioimmunoassay with 125J-gastrin as tracerhormon. High immuno-reactivity could be demonstrated in the grey and white matter of the human cortex as well as in the putamen and nucleus caudatus using this assay. By comparing the unknown brain substance with different peptides in different physico-chemical systems, the brain substance was shown to be homogenous and being similar to CCK-8.