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Lethal orphenadrine intoxication: report of a case.
Zeitschrift Fur Rechtsmedizin. Journal of Legal Medicine
|March 8, 1979
Summary
This case report details a fatal orphenadrine intoxication, highlighting significant liver damage. The primary finding was centrilobular necrosis, a severe form of liver injury.
Area of Science:
- Toxicology
- Pathology
- Pharmacology
Background:
- Orphenadrine is a muscle relaxant and antihistamine.
- Drug intoxication can lead to severe organ damage.
Observation:
- A case of lethal orphenadrine intoxication was documented.
- Anatomical and toxicological examinations were performed.
Findings:
- The most prominent histological finding was centrilobular necrosis of the liver.
- This indicates severe liver injury resulting from the intoxication.
Implications:
- This case underscores the potential toxicity of orphenadrine.
- Understanding the pathological effects is crucial for clinical management of overdose cases.