Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperlipoproteinemia in fasting ponies.

M D Morris, D B Zilversmit, H F Hintz

    Journal of Lipid Research
    |May 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Fasting ponies developed a unique pre-beta very low density lipoprotein (VLDL) in plasma. This suggests impaired VLDL utilization contributes to fasting hyperlipoproteinemia in ponies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Phylogenetic analysis of full-length, early infection, hepatitis C virus genomes among people with intravenous drug use: the InC<sup>3</sup> Study.

    Journal of viral hepatitis·2016
    Same author

    Analysis of resistance-associated substitutions in acute hepatitis C virus infection by deep sequencing across six genotypes and three continents.

    Journal of viral hepatitis·2016
    Same author

    A longitudinal study of hepatitis C virus testing and infection status notification on behaviour change in people who inject drugs.

    Journal of epidemiology and community health·2015
    Same author

    Fracture healing with alendronate treatment in the Brtl/+ mouse model of osteogenesis imperfecta.

    Bone·2013
    Same author

    Social, economic, and psychological impacts of MDR-TB treatment in Tijuana, Mexico: a patient's perspective.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2013
    Same author

    Characterization of the effects of postextraction treatments on human dentin-resin interface by micro-Raman spectroscopy.

    Journal of biomedical optics·2012

    Area of Science:

    • Lipid metabolism and lipoprotein research
    • Comparative animal physiology
    • Endocrinology and metabolic disorders

    Background:

    • Fasting is known to induce significant alterations in plasma lipid profiles across various species.
    • Understanding species-specific lipoprotein responses to metabolic stress is crucial for comparative physiology.
    • Previous studies have documented fasting-induced hyperlipoproteinemia, but the specific lipoprotein changes in ponies are less characterized.

    Purpose of the Study:

    • To investigate the alterations in plasma very low density lipoprotein (VLDL) during prolonged fasting in ponies.
    • To characterize the biochemical properties of the fasting-induced VLDL fraction in ponies.
    • To explore the potential mechanisms underlying fasting-induced hyperlipoproteinemia in this species.

    Main Methods:

    Related Experiment Videos

    • Ponies were subjected to fasting for up to 8 days.
    • Plasma lipoproteins were analyzed using agarose electrophoresis and preparative ultracentrifugation.
    • Cholesterol and triglyceride concentrations were measured, and Triton WR 1339 was injected to assess lipid clearance.

    Main Results:

    • Fasting ponies exhibited a novel pre-beta-migrating VLDL fraction in their plasma.
    • This pony VLDL contained less cholesterol than human/rat VLDL, with 85% being unesterified.
    • Plasma triglyceride levels increased dramatically (20 to 1000 mg/dl) by day 8, showing high inter-individual variability.

    Conclusions:

    • Fasting in ponies induces a distinct VLDL profile, differing from that observed in humans and rats.
    • The observed hypertriglyceridemia suggests impaired catabolism of VLDL rather than overproduction.
    • These findings indicate that impaired very low density lipoprotein utilization is a key factor in fasting-induced hyperlipoproteinemia in ponies.