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Herpesviruses and oncogenesis.

G Klein

    Proceedings of the National Academy of Sciences of the United States of America
    |April 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Herpesviruses are linked to cancer development. These viruses act as causative agents in various animal tumors and may play a role in human lymphomas.

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    Area of Science:

    • Oncology
    • Virology
    • Pathogenesis

    Background:

    • Herpesviruses are known to infect a wide range of hosts.
    • Several herpesviruses have been associated with tumor development in animals.
    • The role of herpesviruses in human oncogenesis is an area of ongoing research.

    Purpose of the Study:

    • To review the evidence linking herpesviruses to oncogenesis.
    • To explore the potential role of herpesviruses in the development of neoplasms.
    • To investigate the association between herpesviruses and specific human lymphomas.

    Main Methods:

    • Literature review of studies on herpesviruses and cancer.
    • Analysis of etiological roles in animal neoplasms.
    • Examination of suggestive evidence in human lymphomas.

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    Main Results:

    • Herpesviruses identified as etiologic agents in chicken, primate, and frog neoplasms.
    • Suggestive evidence indicates a potential contribution to human lymphoma genesis.
    • Herpesvirus oncogenesis demonstrated across multiple species.

    Conclusions:

    • Herpesviruses are significant factors in oncogenesis across various species.
    • Further research is warranted to elucidate the mechanisms of herpesvirus-induced human lymphomas.
    • Herpesviruses represent a potential etiological link to certain human cancers.