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Related Experiment Videos

Left ventricular performance during and after sickle cell crisis.

J Val-Mejias, W K Lee, A B Weisse

    American Heart Journal
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Sickle cell anemia crises do not significantly impact left ventricular function acutely. However, chronic sickle cell disease may lead to cumulative cardiac changes and long-term heart dysfunction.

    Area of Science:

    • Cardiology
    • Hematology
    • Physiology

    Background:

    • Microvascular occlusion is a suspected cause of sickle cell anemia (SCA) cardiac pathophysiology.
    • The impact of SCA on left ventricular (LV) function during crisis remains unclear.
    • Previous studies suggest potential cardiac involvement in SCA.

    Purpose of the Study:

    • To assess LV performance during SCA crises using noninvasive methods.
    • To investigate potential chronic cardiac alterations in SCA patients.
    • To differentiate acute effects from long-term cardiac changes in SCA.

    Main Methods:

    • Systolic time interval (STI) method used for noninvasive LV function assessment.
    • Serial evaluations during SCA crisis and recovery.
    • Echocardiography performed on SCA patients between crises.

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  • Comparison of SCA patients with normal subjects and those with chronic anemia.

    • Main Results:

    • No significant changes in STI were observed during SCA crisis or recovery.
    • Serum CPK-MB and ECG findings did not indicate acute myocardial necrosis during crisis.
    • SCA patients over 23 years old showed abnormal PEP/LVET ratio and ejection fraction compared to younger patients.
    • Enhanced end-diastolic diameter was noted in older SCA patients.

    Conclusions:

    • Acute myocardial ischemia is unlikely during SCA crises.
    • Chronic hemolytic processes in SCA may cause cumulative myocardial damage.
    • Long-term cardiac malfunction can occur in SCA, particularly in older individuals.
    • Age-related cardiac changes may be accelerated or exacerbated by chronic SCA.