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Summary
Pituitary gigantism can cause severe muscular weakness due to peripheral neuropathy. Muscle biopsies in one patient also suggested myopathy, indicating complex neuromuscular involvement.
Area of Science:
- Neurology
- Endocrinology
- Muscle Physiology
Background:
- Pituitary gigantism is a rare condition caused by excessive growth hormone production.
- Muscular weakness is not a commonly reported symptom in pituitary gigantism.
Purpose of the Study:
- To investigate the cause of severe muscular weakness in two patients with pituitary gigantism.
Main Methods:
- Clinical examination of two patients with pituitary gigantism.
- Neurological assessment including tests for peripheral neuropathy.
- Histological examination of muscle biopsies.
Main Results:
- Both patients exhibited peripheral neuropathy.
- One patient's muscle biopsy showed histological features indicative of myopathy.
Conclusions:
- Peripheral neuropathy is a significant finding in pituitary gigantism associated with muscular weakness.
- Myopathy may also contribute to neuromuscular deficits in some cases of pituitary gigantism.