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Tumor etiology and chromosome pattern.

F Mitelman, J Mark, G Levan

    Science (New York, N.Y.)
    |June 23, 1972
    PubMed
    Summary
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    Fibrosarcomas in hamsters and rats show nonrandom chromosome changes. Tumors from virus or chemical carcinogens have distinct karyotypes, despite similar histology.

    Area of Science:

    • Oncology
    • Genetics
    • Carcinogenesis

    Background:

    • Fibrosarcomas are malignant tumors originating from connective tissue.
    • Carcinogenesis can be induced by viral agents or chemical mutagens.
    • Chromosomal abnormalities are common in cancer development.

    Purpose of the Study:

    • To investigate the chromosomal variations in fibrosarcomas induced by Rous sarcoma virus and 7,12-dimethylbenz(a)anthracene in Chinese hamsters and rats.
    • To compare the karyotypic patterns of virus-induced versus chemically-induced fibrosarcomas within the same host species.

    Main Methods:

    • Induction of fibrosarcomas in Chinese hamsters and rats using Rous sarcoma virus and 7,12-dimethylbenz(a)anthracene.
    • Histological examination of tumor samples.

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  • Karyotypic analysis of tumor cells to identify chromosomal variations.

    • Main Results:

    • Fibrosarcomas induced by both methods exhibited nonrandom chromosome variations.
    • Tumors induced by Rous sarcoma virus in rats and Chinese hamsters showed distinct karyotypic patterns.
    • Tumors induced by 7,12-dimethylbenz(a)anthracene in rats and Chinese hamsters also displayed unique karyotypic profiles.
    • Despite histological similarities, virus-induced and chemical-induced tumors within each species had completely different karyotypic patterns.

    Conclusions:

    • The etiological agent (virus or chemical) significantly influences the chromosomal abnormalities in induced fibrosarcomas.
    • Karyotypic patterns can differentiate between virus-induced and chemically-induced fibrosarcomas, even when histologically similar.
    • Nonrandom chromosomal variation is a hallmark of fibrosarcoma development regardless of the inducing agent.