Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrophysiological studies in alcoholism.

E Blackstock, G Rushworth, D Gath

    Journal of Neurology, Neurosurgery, and Psychiatry
    |June 1, 1972
    PubMed
    Summary

    Alcohol affects nerve function, impairing smaller motor and sensory nerve fibers in both alcoholic patients with and without neuropathy. Larger motor fibers often remain unaffected, suggesting specific nerve fiber vulnerability.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of Iron in Subnutrition.

    British medical journal·2010
    Same author

    Treatment of Pediculosis Capitis.

    British medical journal·2010
    Same author

    Cognitive therapy for premenstrual syndrome: a controlled trial.

    Journal of psychosomatic research·1998
    Same author

    The assessment of depression in peri-menopausal women.

    Maturitas·1998
    Same author

    The psychological effects of laparoscopy on women with chronic pelvic pain.

    Psychological medicine·1997
    Same author

    Predictors of treatment outcome for major depression in primary care.

    Psychological medicine·1997

    Area of Science:

    • Neuroscience
    • Clinical Neurology
    • Electrophysiology

    Background:

    • Alcohol abuse is a significant cause of peripheral neuropathy.
    • The specific nerve fiber types affected by alcohol's neurotoxic effects require further elucidation.
    • Understanding the pattern of nerve involvement is crucial for diagnosis and management.

    Purpose of the Study:

    • To investigate the functional status of different nerve fiber types in alcoholic patients.
    • To differentiate nerve involvement patterns in alcoholics with and without clinical neuropathy.
    • To explore the pathological basis of alcohol-induced nerve damage.

    Main Methods:

    • Electrophysiological techniques were employed to assess nerve fiber function.
    • Assessment included both motor and sensory nerve fibers of varying calibers.
    • Patients with and without diagnosed alcoholic neuropathy were studied.

    Main Results:

    • Impaired function was observed in smaller caliber motor fibers.
    • Distal large cutaneous sensory nerve fibers showed impaired function.
    • Proximal Ia sensory fibers exhibited some involvement, but large motor fibers were mostly normal.
    • These findings were consistent in patients with and without clinical neuropathy.

    Conclusions:

    • Alcohol's neurotoxicity selectively affects specific nerve fiber populations.
    • Smaller motor and distal sensory fibers are particularly vulnerable.
    • The pathological process in alcoholic neuropathy involves specific fiber types, with larger motor fibers often preserved.

    Related Experiment Videos