Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A blocking factor in amniotic fluid causing leukocyte migration enhancement.

N Gleicher, C J Cohen, T D Kerenyi

    American Journal of Obstetrics and Gynecology
    |February 15, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preliminary report of intraovarian injections of autologous platelet-rich plasma (PRP) in extremely poor prognosis patients with only oocyte donation as alternative: a prospective cohort study.

    Human reproduction open·2022
    Same author

    In science truth ultimately wins, and PGT-A is no exception.

    Human reproduction (Oxford, England)·2022
    Same author

    IVF outcomes of embryos with abnormal PGT-A biopsy previously refused transfer: a prospective cohort study.

    Human reproduction (Oxford, England)·2022
    Same author

    The ovarian sensitivity index is predictive of live birth chances after IVF in infertile patients.

    Human reproduction open·2020
    Same author

    The 2019 PGDIS position statement on transfer of mosaic embryos within a context of new information on PGT-A.

    Reproductive biology and endocrinology : RB&E·2020
    Same author

    Age, body weight and ovarian function affect oocyte size and morphology in non-PCOS patients undergoing intracytoplasmic sperm injection (ICSI).

    PloS one·2019
    Same journal

    Association of Surgical Approach with Oncologic Outcomes in Low-Risk Cervical Cancer.

    American journal of obstetrics and gynecology·2026
    Same journal

    Trends in Infertility Treatments by Race, Ethnicity, Socioeconomic Status, and Region in U.S. Birth Certificates from Live Births: 2011-2022.

    American journal of obstetrics and gynecology·2026
    Same journal

    Likelihood ratios enhance clinical interpretation of metagenomic prediction of early-onset neonatal sepsis in preterm premature rupture of membranes (Letter-to-the-Editor).

    American journal of obstetrics and gynecology·2026
    Same journal

    Taking risk stratification in preterm premature rupture of membranes to the bedside (Reply to Letter-to-the-Editor).

    American journal of obstetrics and gynecology·2026
    Same journal

    Gestational Age at Full-Term Delivery and Long-Term Offspring Morbidity in Low-Risk Pregnancies: A Population-Based Cohort Study.

    American journal of obstetrics and gynecology·2026
    Same journal

    Trajectories of childbirth-related posttraumatic stress symptoms after a vaginal delivery: a multicenter prospective study.

    American journal of obstetrics and gynecology·2026
    See all related articles

    Amniotic fluid significantly enhances leukocyte migration in pregnant individuals, suggesting a role in maternal immune tolerance. This effect may involve a blocking factor in amniotic fluid that prevents immune recognition of fetal antigens.

    Area of Science:

    • Immunology
    • Reproductive Biology
    • Obstetrics

    Background:

    • Maternal immune tolerance is crucial for successful pregnancy.
    • The role of amniotic fluid in modulating the maternal immune response is not fully understood.

    Purpose of the Study:

    • To investigate the effect of amniotic fluid on leukocyte migration in vitro.
    • To explore potential mechanisms of immune modulation during pregnancy.

    Main Methods:

    • Leukocyte migration inhibition assay was performed using various antigens.
    • Amniotic fluid (AF) from different stages of pregnancy and postpartum periods was tested.
    • Comparisons were made with ovarian tumor homogenate, choriocarcinoma spent medium, and placental pool homogenate.

    Main Results:

    Related Experiment Videos

    • Amniotic fluid significantly enhanced leukocyte migration during the second and third trimesters and postpartum compared to control antigens (p < 0.01).
    • Minimal non-specific activity was observed when comparing pregnant and nonpregnant controls (p < 0.1).
    • The enhancing effect was abolished by dilution but not by antibodies to estrogen or hCG, suggesting a non-hormonal blocking factor.

    Conclusions:

    • Amniotic fluid contains a factor that enhances leukocyte migration, potentially contributing to maternal immune tolerance.
    • This factor may act by blocking the recognition of fetoplacental antigens by the maternal immune system.
    • In vitro leukocyte migration enhancement may correlate with in vivo graft enhancement during pregnancy.