The effect of membrane parameters on the properties of the nerve impulse

The effect of varying membrane capacitance, conductance, and rate constants on the properties of the nerve impulse is considered in terms of the degree of regeneration in the Hodgkin-Huxley model for the squid giant axon. It is shown through computer simulation that reducing regeneration generally increases the duration of the action potential and decreases its amplitude, rate of rise, and conduction velocity. The threshold becomes much less sharp and the amplitude of the response of a patch of membrane grades with stimulus strength. A second stimulus, applied shortly after a first stimulus, considerably perturbs the membrane potential from its original time-course. Under certain conditions, the nerve signal can propagate with a small decrement.