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Efficacy of pertussis vaccines: a brighter horizon

N W Preston, T N Stanbridge

    British Medical Journal
    |August 19, 1972
    PubMed

    Insights

    Recent pertussis vaccines are more effective than older ones, offering better protection against various Bordetella pertussis serotypes. Optimal immunization schedules and vaccines containing all three pertussis agglutinogens are crucial for preventing infections.

    Area of Science:

    • Pediatrics
    • Immunology
    • Microbiology

    Background:

    • Pertussis (whooping cough) remains a significant childhood illness.
    • Vaccine effectiveness can vary based on manufacturing date and circulating Bordetella pertussis serotypes.

    Purpose of the Study:

    • To evaluate the effectiveness of pertussis vaccines manufactured before and after 1967.
    • To identify predominant Bordetella pertussis serotypes and factors influencing serotype changes during infection.

    Main Methods:

    • Analysis of pertussis infections in 186 children under 11 years old.
    • Comparison of vaccine effectiveness based on manufacturing dates and Bordetella pertussis serotypes.

    Main Results:

    • Vaccines manufactured from 1967 onwards showed improved effectiveness against diverse Bordetella pertussis serotypes compared to earlier vaccines.
    • Four doses of recent vaccine were associated with a low incidence of positive cultures.
    • Simultaneous infections with multiple serotypes were common, with type 1,3 being predominant.

    Conclusions:

    • Modern pertussis vaccines demonstrate broader efficacy across different serotypes.
    • Adequate immunization schedules and vaccines containing all three pertussis agglutinogens are essential for effective pertussis prevention.

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