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Related Experiment Videos

Urinary MHPG excretion in minimal brain dysfunction and its modification by d-amphetamine.

W O Shekim, H Dekirmenjian, J L Chapel

    The American Journal of Psychiatry
    |May 1, 1979
    PubMed
    Summary

    Hyperactive boys showed lower 3-methoxy-4-hydroxyphenlyglycol (MHPG) excretion. D-amphetamine reduced MHPG in responders, who also had more soft neurologic signs, but MHPG levels did not predict response.

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    Area of Science:

    • Neuroscience
    • Child Psychology
    • Pharmacology

    Background:

    • Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
    • Biochemical markers, such as MHPG, are investigated for diagnostic and therapeutic insights.
    • Soft neurologic signs may indicate underlying neurological differences in hyperactive individuals.

    Purpose of the Study:

    • To investigate MHPG excretion differences between hyperactive boys and controls.
    • To examine the effect of d-amphetamine on MHPG excretion in hyperactive boys.
    • To explore the relationship between MHPG levels, soft neurologic signs, and d-amphetamine response.

    Main Methods:

    • Urine MHPG levels were measured in 15 hyperactive boys and 13 controls.
    • Hyperactive boys received d-amphetamine for two weeks.

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  • Soft neurologic signs were assessed, and clinical drug response was evaluated.

    • Main Results:

    • Hyperactive boys exhibited significantly lower MHPG excretion compared to controls.
    • D-amphetamine significantly decreased MHPG excretion in drug responders but not non-responders.
    • Drug responders presented with more soft neurologic signs than non-responders.
    • Pretreatment MHPG levels did not predict clinical response to d-amphetamine.
    • Soft neurologic signs were not correlated with baseline MHPG levels.

    Conclusions:

    • Reduced MHPG excretion may be a biomarker for hyperactivity in boys.
    • The interaction between MHPG, soft neurologic signs, and d-amphetamine response warrants further investigation.
    • Soft neurologic signs might be more indicative of treatment response than baseline MHPG levels.