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Effect of Friend leukemia virus and Rowson-Parr virus on immunological maturation of mice
Abstract:
The effect of neonatal infection with Friend virus (FV) and Rowson-Parr virus (RPV) on the maturation of the capacity to respond to sheep red cells, as measured by the numbers of hemolytic plaque-forming cells in the spleen, was investigated in BALB/c mice. Both viruses affected immunological maturation but there were significant differences between their effects. The development with age of the ability to produce plaque-forming cells in response to antigen was virtually abolished by FV and only slightly impaired by RPV. Furthermore, FV also suppressed the development of background plaque-forming cells, whereas RPV did not.
Insights
Neonatal infection with Friend virus (FV) severely impairs immune development in mice, while Rowson-Parr virus (RPV) has a milder effect. FV nearly abolished the ability to form antibody-producing cells, unlike RPV.
Area of Science:
- Immunology
- Virology
- Developmental Biology
Background:
- Neonatal infections can disrupt immune system development.
- Friend virus (FV) and Rowson-Parr virus (RPV) are known viral agents affecting mice.
Purpose of the Study:
- To investigate the impact of neonatal FV and RPV infection on the maturation of immune responses in BALB/c mice.
- To compare the differential effects of FV and RPV on immunological maturation.
Main Methods:
- BALB/c mice were infected neonatally with either FV or RPV.
- The capacity to respond to sheep red blood cells was assessed by measuring hemolytic plaque-forming cells in the spleen.
- Development of background plaque-forming cells was also evaluated.
Main Results:
- Both FV and RPV significantly affected immunological maturation, but with distinct differences.
- FV infection virtually abolished the age-dependent development of plaque-forming cells in response to antigen.
- RPV infection only slightly impaired this development.
- FV suppressed the development of background plaque-forming cells, whereas RPV did not.
Conclusions:
- Neonatal Friend virus infection has a profound and detrimental effect on the maturation of T-dependent antibody responses.
- Rowson-Parr virus infection causes a less severe impairment of immune maturation compared to FV.
- The findings highlight differential impacts of viral infections on immune development.