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[Enflurane anaesthesia and plasma cortisol (author's transl)]
Der Anaesthesist
|March 1, 1979
Summary
Enflurane anesthesia during abdominal surgery causes a slight drop in plasma cortisol initially, followed by a significant increase throughout the procedure and recovery. No direct link was found between enflurane levels and cortisol response.
Area of Science:
- Anesthesiology
- Endocrinology
- Pharmacology
Context:
- General anesthesia and abdominal operations present physiological challenges.
- Adrenocortical function is crucial for stress response during surgery.
- Enflurane is an inhaled anesthetic agent.
Purpose:
- To investigate the impact of enflurane on adrenocortical function.
- To measure plasma cortisol levels during and after enflurane anesthesia.
- To explore the relationship between enflurane concentration and cortisol levels.
Summary:
- Plasma cortisol levels were measured using radioimmunoassay during general anesthesia with enflurane, nitrous oxide, oxygen, and pancuronium.
- A slight decrease in plasma cortisol was observed 30 minutes post-anesthesia induction, followed by a marked, continuous increase intra- and postoperatively.
- Gas chromatography revealed no correlation between plasma enflurane concentrations and cortisol levels.
Impact:
- Provides insights into the neuroendocrine stress response during enflurane anesthesia.
- Highlights the dynamic changes in cortisol levels under anesthetic conditions.
- Informs clinical management of patients undergoing surgery with enflurane.