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Related Experiment Videos

Respiratory allergy to algae: clinical aspects.

A Mittal, M K Agarwal, D N Shivpuri

    Annals of Allergy
    |April 1, 1979
    PubMed
    Summary

    This study identifies allergenic algae in Delhi, finding that certain algae extracts trigger allergic reactions in patients with naso-bronchial allergy. These findings are crucial for understanding and managing airborne allergies.

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    Area of Science:

    • Environmental Science
    • Allergology
    • Immunology

    Background:

    • Naso-bronchial allergy is a significant health concern in urban areas.
    • Identifying specific environmental allergens is crucial for effective management.
    • Algae are increasingly recognized as potential aeroallergens.

    Purpose of the Study:

    • To investigate the allergenic potential of common algae in the Delhi atmosphere.
    • To correlate skin test reactivity with other allergic diagnostic tests.
    • To assess total IgE levels in relation to algal allergy.

    Main Methods:

    • Conducted 4,000 skin tests on 400 patients with naso-bronchial allergy and 300 tests on healthy controls.
    • Utilized extracts from 10 common algae species isolated from Delhi's atmosphere.
    • Performed Prausnitz-Küstner (PK), bronchial provocation, and conjunctival tests.

    Main Results:

    • Positive skin reactions to algal extracts varied, with Lyngbya major (25.7%) and Oscillatoria simplicissima (1.7%) showing the highest and lowest reactivity, respectively.
    • In patients with positive skin tests, PK tests were positive in 70.9%, bronchial provocation in 50%, and conjunctival tests in 48.5%.
    • Total IgE levels were significantly higher in allergic patients (1,225-1,550 IU/ml) compared to healthy volunteers (<885 IU/ml).

    Conclusions:

    • Specific algae species prevalent in Delhi's atmosphere act as significant allergens.
    • Skin test results correlate with other diagnostic methods for allergy confirmation.
    • Elevated IgE levels are indicative of allergic responses to environmental triggers like algae.

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