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Published on: April 2, 2013

Pulmonary sequelae of acute Legionnaires' disease pneumonia

J A Blackmon, R A Harley, M D Hicklin

    Annals of Internal Medicine
    |April 1, 1979
    PubMed

    Insights

    Legionnaires

    Area of Science:

    • Pulmonary Medicine
    • Infectious Diseases
    • Pathology

    Background:

    • Legionnaires' disease (LD) is a severe pneumonia.
    • Long-term pulmonary consequences of LD are not fully understood.

    Purpose of the Study:

    • To investigate chronic pulmonary changes following acute Legionnaires' disease pneumonia.

    Main Methods:

    • Histologic examination of lung specimens from LD survivors and deceased patients.
    • Direct fluorescent antibody technique and Dieterle silver stain to identify LD organisms.

    Main Results:

    • Histology revealed organizing pneumonia, interstitial inflammation, and fibrosis, not acute pneumonia.
    • LD organisms were not detected in chronic specimens.
    • Lung parenchyma did not fully restore to normal in some patients.

    Conclusions:

    • Legionnaires' disease pneumonia can lead to persistent chronic pulmonary changes.
    • These changes include organizing pneumonia and fibrosis, indicating incomplete resolution.

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