Related Experiment Video

Updated: Aug 16, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

[Physiopathology of osteoporosis (author's transl)]

J P Camus, A Prier, J Crouzet

    Annales De Medecine Interne
    |January 1, 1979
    PubMed

    Keywords:
    Age Factors--complicationsBiologyDemographic FactorsEndocrine SystemEstrogensHealthHormonesNutritionPhysiologyPopulationPopulation Characteristics

    More Related Videos

    Osteoclast Derivation from Mouse Bone Marrow06:17

    Osteoclast Derivation from Mouse Bone Marrow

    Published on: November 6, 2014

    Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model08:42

    Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

    Published on: July 3, 2020

    Related Concept Videos

    What is the Skeletal System?01:02

    What is the Skeletal System?

    Overview
    Bone Structure01:55

    Bone Structure

    Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
    Bone Remodeling01:40

    Bone Remodeling

    Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
    Osteoclasts in Bone Remodeling01:31

    Osteoclasts in Bone Remodeling

    Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
    Bone Disorders01:29

    Bone Disorders

    Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
    Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
    Hormones and Bone Tissue01:17

    Hormones and Bone Tissue

    The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
    Hormones That Influence Osteoblasts and/or Maintain the Matrix
    Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...