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Related Experiment Videos

Lomotil poisoning in children.

J A Curtis, K M Goel

    Archives of Disease in Childhood
    |March 1, 1979
    PubMed
    Summary

    Diphenoxylate (Lomotil) overdose in children can cause severe symptoms like coma and respiratory depression. Prompt gastric lavage and naloxone administration are crucial for managing diphenoxylate poisoning in pediatric patients.

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    Area of Science:

    • Pediatric Toxicology
    • Emergency Medicine
    • Pharmacology

    Background:

    • Diphenoxylate (Lomotil) is an antidiarrheal agent.
    • Pediatric ingestion of diphenoxylate can lead to significant toxicity.
    • Previous literature on pediatric diphenoxylate poisoning is limited.

    Purpose of the Study:

    • To describe the clinical presentation and outcomes of pediatric diphenoxylate ingestions.
    • To evaluate the effectiveness of gastric lavage and naloxone in managing diphenoxylate poisoning.
    • To assess the safety of diphenoxylate as an antidiarrheal in children.

    Main Methods:

    • Retrospective case series of 45 children admitted for diphenoxylate ingestion.
    • Clinical data including symptoms, ingested dose, and treatment were analyzed.
    • Outcomes such as mortality, sequelae, and treatment response were recorded.

    Main Results:

    • 45 children ingested diphenoxylate, with one fatality; 44 recovered without sequelae.
    • Common symptoms included coma (4), drowsiness (32), and respiratory depression (9).
    • No dose-response correlation was observed; gastric lavage and naloxone were utilized.

    Conclusions:

    • Diphenoxylate poisoning in children can cause severe central nervous system and respiratory depression.
    • Gastric lavage is recommended even with delayed presentation due to the drug's effect on gut motility.
    • Naloxone is the recommended antagonist for respiratory depression or coma.
    • The use of Lomotil in children warrants careful consideration due to potential toxicity.

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