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Leukemia virus activation during homograft rejection
Science (New York, N.Y.)
|May 4, 1973
Summary
Murine leukemia virus activation occurred in mice receiving skin grafts and immunosuppression. This viral activation was dependent on both the skin graft and antilymphocyte serum treatment.
Area of Science:
- Immunology
- Virology
- Oncology
Background:
- Murine leukemia viruses (MLVs) are retroviruses known to infect rodents.
- Viral activation can be spontaneous or induced by various factors.
- The XC assay is a standard method for detecting infectious MLV.
Purpose of the Study:
- To investigate the effect of xenotransplantation on MLV activation.
- To determine the role of immunosuppression in MLV activation.
- To assess the combined effect of skin grafting and immunosuppression on MLV activation.
Main Methods:
- A/J mouse skin was transplanted onto immunosuppressed BALB/c mice.
- Antilymphocyte serum was administered to some groups of mice.
- The XC assay was used to detect MLV activation in mouse tissues.
Main Results:
- MLV activation was detected in mice receiving both A/J skin grafts and antilymphocyte serum.
- No MLV activation was observed in mice receiving only skin grafts or only antilymphocyte serum.
- MLV activation was absent in control mice that received no treatment.
Conclusions:
- Xenotransplantation combined with immunosuppression can activate latent murine leukemia viruses.
- Both the allogeneic skin graft and the immunosuppressive treatment are necessary for MLV activation.
- These findings highlight the potential for viral reactivation in the context of transplantation and immunosuppression.