[Histometric changes in the liver of inbred rats during prevention of hypokinesis]

An experimental investigation on morphological changes in the liver under prophylaxis of hypokinesia has been performed in genetically uniform material--150 premature rats of August and Wistar lines. The prophylaxis has been carried out at hypokinesia as the background produced by training in the treadban and at the combination of the latter with a pharmacological stimulator. The experiment has been performed for two months. In histological preparations of the liver the number of hepatic lobules, hepatocytes and stellate reticuloendotheliocytes per unit of the tissue area have been determined. Nuclear diameters, width of hepatocytes and sinusoid blood capillaries have been measured. Significant histometric changes in structural components of the liver have been stated after 60 days of hypokinesia with decrease of the organ. Prophylactic measures applied with hypokinesia as the background produce certain positive effect, though it is not the same in different indices and in different strains of animals.