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Related Experiment Video

Updated: Feb 28, 2026

In Vivo Methods to Assess Retinal Ganglion Cell and Optic Nerve Function and Structure in Large Animals
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Visual evoked responses in pernicious anemia.

J Troncoso, E L Mancall, N J Schatz

    Archives of Neurology
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Pernicious anemia (PA) can affect vision pathways early, even before symptoms appear. Delayed visual evoked responses (VERs) in PA patients highlight the need to test for this condition in myelopathy cases.

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    Area of Science:

    • Neurology
    • Hematology
    • Ophthalmology

    Background:

    • Pernicious anemia (PA) is a hematologic disorder.
    • Subacute combined degeneration is a neurological complication of PA.

    Observation:

    • Three newly diagnosed, untreated pernicious anemia patients presented with symptoms suggesting subacute combined degeneration.
    • Visual evoked responses (VERs) were assessed in these patients.

    Findings:

    • All three patients exhibited delayed VERs.
    • This suggests that visual pathway involvement is a potential early manifestation of PA.
    • This occurs even without overt clinical signs of visual impairment.

    Implications:

    • Pernicious anemia should be considered in differential diagnoses for myelopathy patients with abnormal VERs.
    • Early detection of PA-related visual pathway damage is crucial.
    • VER testing may aid in early PA diagnosis.