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Related Experiment Videos

Trace elements and health: an overview.

E J Underwood

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
    |December 11, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Linking human health to geochemical factors is complex, unlike in farm animals. Endemic goitre provides strong evidence, but technology

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    Area of Science:

    • Environmental Health
    • Geochemistry
    • Human Nutrition

    Background:

    • Relating trace element imbalances in humans to geochemical factors is challenging compared to livestock.
    • Human exposure pathways differ significantly from grazing animals, complicating direct environmental links.
    • Technological advancements have altered the natural geochemical environment, impacting human trace element intake.

    Purpose of the Study:

    • To explore the difficulties in correlating human trace element status with geochemical factors.
    • To examine the influence of technological changes on human exposure to environmental elements.
    • To critically assess the evidence linking the physical environment to human health and disease.

    Main Methods:

    • Comparative analysis of human and animal trace element-environment relationships.

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  • Review of epidemiological data, particularly for endemic goitre.
  • Examination of man-made modifications to the geochemical environment and their health implications.

    • Main Results:

    • Endemic goitre serves as a key example of a geochemical link to human disease.
    • Technological development significantly impacts human intake of essential and toxic elements like Iron (Fe), Iodine (I), Zinc (Zn), Lead (Pb), and Selenium (Se).
    • Distinguishing between mere association and causation in environmental health studies requires rigorous criteria.

    Conclusions:

    • Establishing direct geochemical causality for human trace element disorders is complex.
    • Human health is influenced by environmental factors, with technology playing a significant role in modifying these relationships.
    • Understanding the chemical form and interactions of elements is crucial for setting safe tolerance limits.