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Convolution in human rods: an ageing process.

J Marshall, J Grindle, P L Ansell

    The British Journal of Ophthalmology
    |March 1, 1979
    PubMed
    Summary
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    Age-related nodular excrescences in human rod outer segments increase with aging. These structures result from localized convolutions of rod outer segments, as revealed by electron microscopy.

    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Gerontology

    Background:

    • The aging human retina undergoes various structural changes.
    • Rod photoreceptors are crucial for vision, particularly in low light.
    • Understanding age-related cellular alterations is vital for diagnosing and treating retinal diseases.

    Purpose of the Study:

    • To investigate age-related morphological changes in human rod outer segments.
    • To characterize the nature and formation of nodular excrescences observed in rod outer segments.
    • To correlate the incidence of these structures with donor age.

    Main Methods:

    • Morphological survey of 73 human retinae across a 9-decade age range.
    • Inclusion of 20 retinae from eyes enucleated due to malignant melanoma.

    Related Experiment Videos

  • Electron microscopy for detailed structural analysis of rod outer segments.

    • Main Results:

    • Nodular excrescences were observed in the outer segments of rods.
    • The incidence of these excrescences increased significantly with age.
    • Electron microscopy revealed these structures as localized convolutions of affected outer segments.

    Conclusions:

    • Localized convolutions of rod outer segments, termed nodular excrescences, are an age-dependent phenomenon.
    • These findings provide insights into the structural plasticity of photoreceptor outer segments during aging.
    • Further research can explore the functional implications of these age-related changes in retinal cells.