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Optic neuropathy in ketogenic diet.

C S Hoyt, F A Billson

    The British Journal of Ophthalmology
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Ketogenic diets for seizure control can cause optic neuropathy due to thiamine deficiency. Supplementing with thiamine (vitamin B1) and regular eye exams can prevent vision loss.

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    Area of Science:

    • Neurology
    • Ophthalmology
    • Nutritional Science

    Background:

    • Ketogenic diets are effective in managing refractory epilepsy.
    • Optic neuropathy is a potential, though rare, complication associated with ketogenic diets.
    • Thiamine (vitamin B1) is essential for neuronal function and optic nerve health.

    Observation:

    • Two patients on ketogenic diets for seizure control developed symmetrical, bilateral optic neuropathy.
    • Clinical presentation included visual dysfunction.
    • Laboratory investigations indicated a deficiency in thiamine.

    Findings:

    • Thiamine deficiency was identified as the likely cause of optic neuropathy in these patients.
    • Both patients experienced complete recovery of visual function after thiamine supplementation.

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  • Treatment with thiamine resolved the optic nerve dysfunction.

    • Implications:

    • Routine vitamin B supplementation, including thiamine, should be considered for patients on ketogenic diets.
    • Periodic evaluation of optic nerve function is recommended to monitor for potential dysfunction.
    • Early detection and intervention with thiamine can prevent permanent visual impairment.