Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Arsenic-induced bone marrow toxicity: ultrastructural and electron-probe analysis.

J R Feussner, J D Shelburne, S Bredehoeft

|May 1, 1979

Summary

This study demonstrates arsenic in bone marrow, confirming its role in causing megaloblastic anemia. Tissue arsenic measurements are recommended for diagnosing arsenic poisoning.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Medical care disruptions during the first six months of the COVID-19 pandemic: the experience of older breast cancer survivors.

Breast cancer research and treatment·2021

Same author

Medical Care Disruptions During the First Six-Months of the COVID19 Pandemic: The Experience of Older Breast Cancer Survivors.

Research square·2021

Same author

Race/Ethnic and Educational Disparities in the Association Between Pathogen Burden and a Laboratory-Based Cumulative Deficits Index.

Journal of racial and ethnic health disparities·2019

Same author

Investigating pathogen burden in relation to a cumulative deficits index in a representative sample of US adults.

Epidemiology and infection·2018

Same author

Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511).

Breast cancer research and treatment·2016

Same author

Treatment of mental retardation.

Pediatric annals·2014

Area of Science:

Hematology
Toxicology
Cell Biology

Background:

Arsenic poisoning can cause severe hematologic abnormalities, including megaloblastic anemia.
Previous studies have reported hematologic complications but lacked direct evidence of arsenic in the bone marrow.

Observation:

A patient with severe arsenic poisoning presented with megaloblastic erythropoiesis and other blood/bone marrow abnormalities.
Ultrastructural analysis revealed significant nuclear aberrations in bone marrow cells.

Findings:

Electron probe analysis detected arsenic within bone marrow spicules.
These findings provide direct evidence of arsenic's presence in the bone marrow milieu.
Arsenic exposure is linked to megaloblastic anemia and direct toxicity to DNA synthesis.

Related Experiment Videos

Implications:

Confirms arsenic as a cause of megaloblastic anemia.
Suggests electron probe analysis as a tool for studying arsenic toxicity mechanisms.
Recommends tissue arsenic measurements (hair, nails) over urinary tests for screening arsenic poisoning.