Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Granulocyte function during lithium therapy.

M S Cohen, B Zakhireh, J A Metcalf

    Blood
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Meta-analysis of apparent ruminal synthesis and postruminal flow of B vitamins in dairy cows.

    Journal of dairy science·2022
    Same author

    Abrupt weaning reduces postweaning growth and is associated with alterations in gastrointestinal markers of development in dairy calves fed an elevated plane of nutrition during the preweaning period.

    Journal of dairy science·2017
    Same author

    Glucose supplementation stimulates peripheral branched-chain amino acid catabolism in lactating dairy cows during essential amino acid infusions.

    Journal of dairy science·2015
    Same author

    The influence of age and weaning on permeability of the gastrointestinal tract in Holstein bull calves.

    Journal of dairy science·2015
    Same author

    Essential amino acid infusions stimulate mammary expression of eukaryotic initiation factor 2Bε but milk protein yield is not increased during an imbalance.

    Journal of dairy science·2015
    Same author

    Technical note: Three-dimensional imaging of rumen tissue for morphometric analysis using micro-computed tomography.

    Journal of dairy science·2014
    Same journal

    Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

    Blood·2026
    Same journal

    Identifying steroid-refractory aGVHD before it happens.

    Blood·2026
    Same journal

    ELISA-negative HIT: antibody recognition and relevance.

    Blood·2026
    Same journal

    EBV and immunodeficiency: the odd couple drawn to the brain.

    Blood·2026
    Same journal

    A bone to pick with ferric carboxymaltose.

    Blood·2026
    Same journal

    A step toward streamlining HIT diagnosis.

    Blood·2026
    See all related articles

    Lithium carbonate preserves neutrophil function in patients. This suggests lithium may be useful for treating neutropenic states by supporting white blood cell production.

    Area of Science:

    • Immunology
    • Pharmacology
    • Hematology

    Background:

    • Neutrophils are critical immune cells involved in pathogen defense.
    • Lithium carbonate is a mood-stabilizing drug with potential effects on white blood cell counts.
    • Neutropenia, a condition of low neutrophil count, increases infection risk.

    Purpose of the Study:

    • To investigate the impact of lithium carbonate therapy on neutrophil function.
    • To determine if lithium affects neutrophil migration, chemotaxis, phagocytosis, or bactericidal activity.
    • To assess the potential of lithium as a therapeutic agent for neutropenic conditions.

    Main Methods:

    • Neutrophil function assays were performed on samples from patients receiving lithium carbonate.
    • Functional parameters compared included random migration, chemotaxis, phagocytosis, and bactericidal ability.

    Related Experiment Videos

  • In vitro experiments tested the effects of lithium chloride on control neutrophils and patient sera.

    • Main Results:

    • Neutrophils from patients on lithium carbonate exhibited normal function across all tested parameters.
    • Neither patient sera nor in vitro lithium chloride addition significantly impaired neutrophil functional capacity.
    • No significant alterations in neutrophil migration, chemotaxis, phagocytosis, or bactericidal ability were observed.

    Conclusions:

    • Neutrophil function is preserved in patients undergoing lithium therapy.
    • Lithium carbonate does not adversely affect key neutrophil immune functions.
    • These findings support the potential use of lithium carbonate as a leukopoietic agent in neutropenic states.