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Microchemical analysis for 13 constituents of plasma from healthy children
Insights
This study establishes normal plasma chemical values for 837 healthy children across six age groups. The findings provide essential reference ranges for pediatric clinical chemistry, aiding in the diagnosis of various health conditions.
Area of Science:
- Clinical Chemistry
- Pediatric Medicine
- Biochemistry
Background:
- Establishing accurate reference ranges for plasma chemical constituents is crucial for pediatric health assessment.
- Previous data may not reflect current pediatric populations or analytical methodologies.
Purpose of the Study:
- To determine normal plasma values for 13 key chemical analytes in a large cohort of healthy children.
- To assess age- and sex-related variations in these biochemical markers.
- To provide updated reference ranges for pediatric clinical practice.
Main Methods:
- Analysis of plasma samples from 837 healthy children using two Abbott ABA-100 Bichromatic Analyzers.
- Measurement of 13 chemical constituents including enzymes, electrolytes, lipids, proteins, and metabolites.
- Statistical assessment of age and sex differences to establish distinct normal value ranges.
Main Results:
- Normal values were estimated for lactate dehydrogenase, aspartate aminotransferase, alkaline phosphatase, inorganic phosphorus, total calcium, total cholesterol, total proteins, albumin, uric acid, urea nitrogen, alanine aminotransferase, total bilirubin, and glucose.
- Significant age- and sex-related variations were observed for several analytes.
- Reference ranges were established for six distinct pediatric age groups.
Conclusions:
- The study provides a comprehensive set of updated normal plasma chemical values for healthy children.
- These reference ranges are essential for accurate interpretation of laboratory results in pediatric patients.
- The data supports improved diagnostic accuracy and monitoring of health in children.
Abstract:
Normal values for 13 chemical constituents of plasma were estimated from results for 837 presumably healthy children. Ninety microliters of specimen was analyzed for lactate dehydrogenase, aspartate aminotransferase, alkaline phosphatase, inorganic phosphorus, total calcium, total cholesterol, total proteins, albumin, uric acid, urea nitrogen, alanine aminotransferase, total bilirubin, and glucose. We used two Abbott ABA-100 Bichromatic Analyzers interfaced directly to the ABA Data Management System. For each test age- and sex-related variations were assessed and normal values were estimated for six different age groups.