Acetylcholinesterase activity and its molecular forms in rectal tissue in the diagnosis of Hirsprung's disease

Acetylcholinesterase (AChE) activity and its molecular forms in the rectal tissue in Hirsprung's disease were studied. Total AChE activity was increased in Hirsprung's disease; the activity was separated by polyacrylamide gel electrophoresis into two molecular forms. The AChE form with higher electrophoretic mobility was not observed in healthy children, and it might be of diagnostic importance in this disease.