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Relationships between the haemolytic activities of the human complement system and complement components.

A Takada, Y Imamura, Y Takada

    Clinical and Experimental Immunology
    |February 1, 1979
    PubMed
    Summary
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    Complement

    Area of Science:

    • Immunology
    • Complement system
    • Hemolytic activity

    Background:

    • The complement system is crucial for innate and adaptive immunity.
    • Understanding the relationships between complement pathways and their components is vital.
    • Hemolytic activity assays are standard for assessing complement function.

    Purpose of the Study:

    • To investigate the correlations between hemolytic activities of the classical pathway (CH50), alternative pathway (AP50), early alternative pathway (CV50), and late complement pathway (C(3--9)H50).
    • To examine the relationships between these activities and specific complement components (C3, C4, C5, C9, B, D).

    Main Methods:

    • Assessed hemolytic activities: CH50, AP50, CV50, and C(3--9)H50.
    • Measured levels of complement components: C3, C4, C5, C9, Factor B, and Factor D.

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  • Analyzed correlations between measured activities and component levels.

    • Main Results:

    • A strong correlation was observed between CH50 and AP50.
    • AP50 showed good correlation with Factor B and CV50.
    • No correlation was found between AP50 and C(3--9)H50, or between C(3--9)H50 and C5 or C9.

    Conclusions:

    • AP50 appears to primarily reflect alterations in the early stages of the alternative pathway.
    • C(3--9)H50 is not significantly influenced by individual changes in C5 or C9 levels.
    • Variations in C5-C9 components may not directly impact overall complement-mediated cell lysis, despite their role in the membrane attack complex formation.