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Acute delirious state after epsilon-amino caproic acid administration
Clinical Toxicology
|January 1, 1979
Summary
A patient experienced a brief, acute delirious episode with hallucinations after receiving epsilon-amino caproic acid (EACA) before an imaging procedure. This rare psychiatric side effect of EACA was not previously documented.
Area of Science:
- Pharmacology
- Neuropsychiatry
Background:
- Intravenous pyelography often requires contrast agents.
- Iodine hypersensitivity is a known patient risk factor.
- Epsilon-amino caproic acid (EACA) is used medically, but its side effect profile is not fully elucidated.
Observation:
- A patient with a history of iodine hypersensitivity received an intravenous bolus of 2 gm EACA.
- Immediately post-injection, the patient exhibited an acute delirious state.
- The episode included auditory, visual, and kinesthetic hallucinations.
Findings:
- The acute episode resolved completely within 8 minutes.
- No residual psychiatric or neurological symptoms were observed post-episode.
- This specific neuropsychiatric side effect of EACA appears to be unreported in existing literature.
Implications:
- Highlights a potential, previously undocumented neuropsychiatric adverse effect of EACA.
- Suggests careful patient monitoring may be warranted following EACA administration, especially in susceptible individuals.
- Underscores the importance of comprehensive adverse event reporting in clinical practice.