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Related Experiment Videos

Fluoride kinetics and renal function during enflurane anaesthesia.

P O Järnberg, J Ekstrand, L Irestedt

    Acta Anaesthesiologica Scandinavica. Supplementum
    |January 1, 1979
    PubMed
    Summary
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    Enflurane anesthesia temporarily reduced kidney function and fluoride excretion in patients. Post-procedure, renal function recovered, and fluoride excretion increased with rising urine pH, suggesting pH-dependent tubular reabsorption.

    Area of Science:

    • Anesthesiology
    • Nephrology
    • Clinical Chemistry

    Background:

    • Enflurane is an anesthetic agent known to be metabolized into inorganic fluoride.
    • The impact of enflurane anesthesia on renal function and fluoride handling requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of enflurane anesthesia on renal function, including urine flow and clearance.
    • To examine fluoride metabolism, serum levels, and excretion patterns during and after enflurane anesthesia.
    • To explore the relationship between urinary pH and fluoride reabsorption in the renal tubules.

    Main Methods:

    • Studied seven patients undergoing enflurane anesthesia.
    • Monitored urine flow rate, inulin clearance, PAH clearance, and fractional sodium excretion.

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  • Measured serum fluoride levels and fractional fluoride excretion.
  • Analyzed correlations between urinary pH and fluoride excretion postoperatively.

    • Main Results:

    • Enflurane anesthesia significantly reduced urine flow, inulin clearance, PAH clearance, and fractional sodium excretion.
    • Renal function returned to baseline levels promptly after anesthesia.
    • Mean maximal serum fluoride level reached 17.4 +/- 3.3 microM.
    • Fractional fluoride excretion decreased to 35% of control during anesthesia.
    • A significant inverse correlation was observed between fractional fluoride excretion and urinary pH postoperatively.

    Conclusions:

    • Enflurane anesthesia transiently impairs renal function.
    • Fluoride excretion is reduced during enflurane anesthesia.
    • Renal tubular reabsorption of fluoride appears to be inversely related to tubular fluid pH, likely via non-ionic diffusion.