[Resorption, distribution and excretion of the Bulgarian preparation, adepren, in experimental animals]

The authors carried out studies of the original Bulgarian preparation Adepren on male rats Wistar with a weight of 170-200 gm. Single groups of animals were treated singly with venous doses respectively 2,5 and 10 mg/kg of body weight, but other three groups with oral administration of 10, 100 and 200 mg/kg of body weight. The content of the preparation was determined after decapitation of the rats at various intervals of time in plasma, brain, liver and kidneys. Excretion was examined in urine and feces for a period of four days and nights (in metabolic cages). There was a slow resorption of Adepren in the gastro-intestinal tract. The preparation underwent biotransformation in the organism of the rats after oral usage and the basic metabolite was 4-aminocholine, excreted in urine. Adepren and its metabolites were excreted in rats mainly through urine.