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Related Experiment Videos

Digoxin-induced decrease in intraocular pressure in the cat.

B L Ferraiolo, D G Pace

    European Journal of Pharmacology
    |April 1, 1979
    PubMed
    Summary

    Digoxin significantly lowered intraocular pressure in cats before causing arrhythmia. This suggests a potential therapeutic effect on eye pressure, possibly via Na-K-ATPase inhibition in the ciliary body.

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    Area of Science:

    • Pharmacology
    • Ophthalmology
    • Cardiology

    Background:

    • Intraocular pressure (IOP) regulation is crucial for ocular health.
    • Cardiac glycosides like digoxin have complex physiological effects.
    • The impact of digoxin on IOP is not fully understood.

    Purpose of the Study:

    • To investigate the effect of digoxin on intraocular pressure in an animal model.
    • To determine the dose-dependent relationship between digoxin administration and IOP changes.
    • To explore potential mechanisms underlying digoxin-induced IOP reduction.

    Main Methods:

    • Anesthetized cats received constant intravenous infusions of digoxin.
    • Intraocular pressure, blood pressure, and heart rate were monitored.
    • A control infusion of diluent was administered to the same animals for comparison.
    • Digoxin doses ranged from 60 micrograms/kg up to the induction of ventricular arrhythmia.

    Main Results:

    • Digoxin caused a progressive decrease in intraocular pressure with increasing doses.
    • A significant 40% decrease in IOP was observed just before ventricular arrhythmia.
    • Control infusions showed only a 10% decrease in IOP (P < 0.05).
    • No significant differences in blood pressure or heart rate were noted between digoxin and control infusions (P < 0.1).

    Conclusions:

    • Digoxin administration leads to a dose-dependent reduction in intraocular pressure in cats.
    • The observed IOP decrease may be linked to the inhibition of Na-K-ATPase in the ciliary body.
    • These findings suggest a potential role for digoxin or related compounds in managing elevated intraocular pressure.

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