Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colchicine-estrogen interactions.

N Soto, A Tchernitchin

    Experientia
    |April 15, 1979
    PubMed
    Summary

    Colchicine impedes eosinophil migration into uterine tissue, preventing swelling and increased eosinophil presence, despite not blocking initial cell recognition. This research clarifies colchicine

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Location and course of the mandibular canal in dentate patients: morphometric study using cone-beam computed tomography.

    Folia morphologica·2019
    Same author

    Meta-Analysis of Decision Impact and Net Decision Change in Adjuvant Chemotherapy Allocation in Early Stage Node-Negative, Estrogen Receptor-Positive Breast Cancer with a 21-Gene Assay.

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
    Same author

    In vitro comparison of output fluid temperatures for room temperature and prewarmed fluids.

    The Journal of small animal practice·2014
    Same author

    Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children.

    Diabetologia·2005
    Same author

    [Non classical subtypes of diabetes mellitus].

    Revista medica de Chile·2001
    Same author

    Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome: a randomized controlled trial.

    JAMA·2001

    Area of Science:

    • Reproductive biology
    • Immunology
    • Pharmacology

    Background:

    • Estrogen plays a role in regulating uterine immune responses.
    • Eosinophils are immune cells implicated in uterine inflammation and edema.
    • Colchicine is a medication with anti-inflammatory properties.

    Purpose of the Study:

    • To investigate the effect of colchicine on estrogen-induced uterine eosinophilia and edema.
    • To determine whether colchicine interferes with eosinophil recognition or migration in the uterus.

    Main Methods:

    • Estrogen administration to induce uterine changes.
    • Administration of colchicine.
    • Microscopic examination of uterine tissue to assess eosinophil presence and location.
    • Evaluation of uterine edema.

    Main Results:

    • Colchicine did not prevent eosinophils from recognizing the uterine blood vessel surface induced by estrogen.
    • Colchicine significantly inhibited the migration of eosinophils through the endothelial lining.
    • Colchicine effectively blocked estrogen-induced uterine eosinophilia and edema.

    Conclusions:

    • Colchicine's mechanism in blocking estrogen-induced uterine inflammation involves inhibiting eosinophil migration, not initial recognition.
    • These findings highlight a specific cellular process targeted by colchicine in the context of uterine immune responses.
    • Colchicine may be a potential therapeutic agent for conditions involving estrogen-mediated uterine inflammation.

    Related Experiment Videos