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Updated: Aug 9, 2026
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Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1
Published on: April 8, 2009
A possible relation between human pathogenicity of smallpox vaccines and virus growth at elevated temperatures
The Journal of Hygiene
|August 1, 1974
Abstract:
Seven smallpox vaccines of known human pathogenicity were tested for their ability to produce pocks on the chick chorioallantois at 39.7 degrees C. Significant differences were found and the more pathogenic strains produced pocks with greater efficiency at 39.7 degrees C. than did strains of average or low pathogenicity.
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01:51Vaccinations
Overview
01:25Increased Body Temperature
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01:27Factors Influencing Microbial Growth: Temperature
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01:23Vaccine Production
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01:24Smallpox
Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
01:20Chickenpox
Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...