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Recurrent cutaneous herpes simplex in hairless mice
Infection and Immunity
|September 1, 1974
Summary
This study shows that immunosuppression with prednisone can reactivate latent herpes simplex virus in healed skin lesions in mice. This finding suggests a new model for studying recurrent cutaneous herpes infections.
Area of Science:
- Virology
- Immunology
- Dermatology
Background:
- Herpes simplex virus (HSV) infections can cause recurrent cutaneous lesions.
- Understanding the mechanisms of HSV recurrence is crucial for developing effective treatments.
Purpose of the Study:
- To establish a new animal model for studying recurrent cutaneous herpes infections.
- To investigate the effect of immunosuppression on latent HSV reactivation.
Main Methods:
- Hairless mice were passively immunized and inoculated with HSV.
- After primary lesion healing, mice received prednisone treatment.
- Herpesvirus was recovered from skin swabs post-treatment.
Main Results:
- Herpesvirus was recovered from 17% of prednisone-treated mice.
- Reactivation occurred 12 to 30 days after initiating immunosuppression.
- This indicates successful reactivation of latent HSV.
Conclusions:
- Prednisone treatment can induce HSV recurrence in a mouse model.
- This model is valuable for understanding and treating recurrent herpes infections.
- Further research can utilize this model to explore therapeutic strategies.