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Plasma tryptophan and sheep.

C N Chen, R S Kalucy, M K Hartmann

    British Medical Journal
    |December 7, 1974
    PubMed
    Summary
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    Plasma tryptophan levels correlate with sleep stages, with higher free tryptophan linked to more REM sleep and less non-REM sleep. Diurnal variations in free tryptophan were observed throughout the night.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Sleep Medicine

    Background:

    • Tryptophan is a precursor to serotonin and melatonin, neurotransmitters crucial for sleep regulation.
    • Understanding the relationship between plasma tryptophan and sleep architecture is important for sleep research.

    Purpose of the Study:

    • To investigate the temporal relationship between plasma tryptophan levels and sleep stages.
    • To examine correlations between free, bound, and total plasma tryptophan and sleep patterns.

    Main Methods:

    • Measurements of free, bound, and total plasma tryptophan (F.P.T., B.P.T., T.P.T.) were taken overnight.
    • All-night polygraphic sleep recordings were conducted on six young female volunteers.

    Main Results:

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    • No direct temporal link was found between plasma tryptophan levels and specific sleep stages.
    • Mean F.P.T. levels positively correlated with REM sleep and negatively with non-REM sleep.
    • An inverse relationship was observed between F.P.T. and B.P.T. levels, with higher F.P.T. in the first half of the night.

    Conclusions:

    • Plasma tryptophan levels, particularly free tryptophan, show correlations with sleep architecture.
    • Free plasma tryptophan exhibits diurnal variation, influencing sleep patterns.
    • Further research is warranted to elucidate the precise mechanisms linking tryptophan metabolism to sleep regulation.