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Related Experiment Videos

Synaptic transmission and cell death during normal ganglionic development.

L Landmesser, G Pilar

    The Journal of Physiology
    |September 1, 1974
    PubMed
    Summary

    During chick embryonic development, half of ciliary ganglion cells undergo programmed cell death. This cell death is linked to failed peripheral connections and transmission failures, ensuring ganglion function.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Cell Biology

    Background:

    • Chick ciliary ganglion development involves significant cell death.
    • Synapse formation occurs on cells that will eventually undergo apoptosis.

    Purpose of the Study:

    • To investigate the timing and causes of cell death in the developing chick ciliary ganglion.
    • To correlate cell death with synaptic transmission and peripheral connection formation.

    Main Methods:

    • Observation of embryonic chick ciliary ganglion development.
    • Analysis of cell numbers, synaptic connections, and neural transmission.
    • Correlation of cell death with peripheral innervation and functional synapse establishment.

    Main Results:

    • Cell death reduces chick ciliary ganglion cells by 50% between Stages 35-39.
    • Synapses form on cells destined to die; transmission failure precedes cell death.
    • Cell death coincides with peripheral connection formation, suggesting a role for inadequate connections.

    Conclusions:

    • Failure to establish adequate peripheral connections is a likely cause of cell death in the ciliary ganglion.
    • Transmission failures may precede cell death, with surviving neurons potentially forming new synapses.
    • Programmed cell death ensures functional integrity of the developing chick ciliary ganglion.

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