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Related Experiment Video

Updated: Jun 23, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

Erythromycin ethylsuccinate-induced cholestasis.

A L Viteri, J F Greene, W P Dyck

Gastroenterology

|May 1, 1979

Summary

This summary is machine-generated.

Erythromycin ethylsuccinate can cause cholestasis, a liver condition. This case report details a patient experiencing jaundice and abdominal pain after taking this antibiotic.

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Published on: August 1, 2018

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Last Updated: Jun 23, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation

Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation

Published on: August 1, 2018

Area of Science:

Hepatology
Pharmacology
Clinical Medicine

Background:

Erythromycin is a widely used macrolide antibiotic.
Drug-induced liver injury is a significant concern in clinical practice.
Cholestasis is a condition where bile flow is interrupted.

Observation:

A 52-year-old female presented with abdominal pain, fever, and jaundice.
These symptoms recurred after re-administration of erythromycin ethylsuccinate.
A similar episode occurred 5 months prior following the same antibiotic exposure.

Findings:

The patient's symptoms are consistent with drug-induced cholestasis.
Erythromycin ethylsuccinate is implicated as the causative agent.
This represents a potential new adverse effect of erythromycin ethylsuccinate.

Implications:

Clinicians should be aware of the potential for erythromycin ethylsuccinate to induce cholestasis.
Further investigation into the mechanism of erythromycin-induced cholestasis is warranted.
This finding may impact antibiotic prescribing practices for susceptible individuals.