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Are viruses important in carcinogenesis?

F Rapp, E R Buss

The American Journal of Pathology

|October 1, 1974

Summary

This summary is machine-generated.

Viruses, including DNA and RNA types, are known causes of animal cancers. This review examines herpesviruses in animals and humans, assessing their cancer-causing potential.

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Area of Science:

Virology
Oncology
Comparative Pathology

Background:

Viruses are established etiological agents in animal cancers.
Both DNA and RNA viruses can induce tumor formation.
Herpesviruses, particularly Epstein-Barr virus, are investigated for human cancer roles.

Purpose of the Study:

To review herpesviruses in lower animals and human cancer candidates.
To assess the oncogenic potential of these viral agents.

Main Methods:

Literature review of viral oncology studies.
Comparative analysis of animal and human herpesviruses.
Assessment of oncogenic evidence.

Main Results:

Herpesviruses are significant in animal oncogenesis.

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Human herpesvirus candidates show oncogenic potential.

Comparative studies highlight conserved oncogenic mechanisms.

Conclusions:

Herpesviruses play a critical role in cancer etiology across species.
Further research into viral oncogenesis is warranted.
Understanding viral-animal cancer links can inform human cancer research.