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[Decrease of ACh response in isolated duodenum from SART stressed (repeated cold stressed) mice (author's transl)].

T Kita, T Hata, J Iida

    Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
    |January 1, 1979
    PubMed
    Summary
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    Repeated cold stress (SART) significantly reduces duodenal muscle response to acetylcholine in mice, indicating autonomic nervous system imbalance. Certain drug pre-treatments can mitigate these effects.

    Area of Science:

    • Gastroenterology
    • Neuroscience
    • Pharmacology

    Context:

    • Stress significantly impacts physiological functions.
    • The autonomic nervous system plays a crucial role in gastrointestinal motility.
    • SART (Sustained and Repeated Stress) is a model for studying chronic stress effects.

    Purpose:

    • To investigate the effects of SART stress on duodenal smooth muscle contractility.
    • To explore the role of the autonomic nervous system in stress-induced gastrointestinal changes.
    • To evaluate the potential of pharmacological interventions to counteract stress-induced duodenal dysfunction.

    Summary:

    • SART stress markedly decreased acetylcholine-induced duodenal contractions in mice, with maximal contraction reduced to 37% of controls.
    • While muscle contractility systems remained intact, pilocarpine and KCl responses were diminished, suggesting neural regulation impairment.

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  • Pretreatment with adrenergic, anticholinergic, and specific tranquilizing drugs, as well as neurotropin, partially inhibited the stress-induced decrease in ACh response.

    • Impact:

    • Findings suggest SART stress induces an autonomic nervous system imbalance, particularly affecting parasympathetic tone in the duodenum.
    • This study highlights the potential of certain drugs in mitigating stress-related gastrointestinal dysmotility.
    • Neurotropin demonstrated a notable inhibitory effect on both duodenal dysfunction and body weight loss.