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Related Experiment Videos

Virus content of smallpox scabs.

A C Mitra, J K Sarkar, M K Mukherjee

    Bulletin of the World Health Organization
    |January 1, 1974
    PubMed
    Summary

    Smallpox virus titers in scabs remained high throughout convalescence in 5 patients. Viral load did not correlate with vaccination status or disease severity, indicating persistent infectiousness.

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    Area of Science:

    • Virology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Smallpox, a highly contagious viral disease, poses significant public health challenges.
    • Understanding smallpox virus shedding dynamics is crucial for disease control and prevention.

    Purpose of the Study:

    • To quantify smallpox virus titers in patient scabs during the convalescent phase.
    • To investigate the relationship between viral load, disease severity, and vaccination status.

    Main Methods:

    • Log titers of smallpox virus were measured in scab samples from 5 patients.
    • Samples were collected between the 13th and 24th days of illness.

    Main Results:

    • Smallpox virus titers ranged from 3.72 to 6.54 log pock-forming units per 0.1 g of scab.
    • No significant decrease in viral titers was observed as patients recovered.
    • Viral load showed no correlation with prior vaccination status or clinical presentation.

    Conclusions:

    • Smallpox virus remains detectable in scabs during convalescence.
    • Infectious virus shedding may persist beyond the acute phase of illness.
    • Vaccination status and disease severity do not appear to influence viral shedding levels in scabs.

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